The hippocampal memory system has been suggested to be well conserved during evolution, demonstrating both structural and functional similarities across species, particularly in mammals ( Manns and Eichenbaum 2006 Allen and Fortin 2013). Hippocampus, mammalian brain evolution, mouse connectivity atlas, mouse fMRI, resting state Introduction Collectively, these findings indicate that sensory cortical networks are coupled to the mouse but not the human hippocampal memory system, suggesting that the emergence of expanded and new association areas in humans resulted in the rerouting of cortical information flow and dissociation of primary sensory cortices from the hippocampus. Supporting this observation in humans but not in mice, sensory and association cortical networks are connected to spatially distinct subregions within the parahippocampal region. Finally, comparing cortico-hippocampal connectivity across species, we discovered preferential hippocampal connectivity of sensory cortical networks in mice compared with preferential connectivity of association cortical networks in humans.
![hippocampus anatomy and visual cortex mouse hippocampus anatomy and visual cortex mouse](https://i.ytimg.com/vi/5EyaGR8GGhs/maxresdefault.jpg)
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Moreover, we identified a similar topographical modality-specific organization along the longitudinal axis of the mouse hippocampus, indicating that sensory information arriving at the hippocampus is only partly integrated. We found that fcMRI recapitulates anatomical connectivity, demonstrating sensory mapping within the mouse parahippocampal region. To address this question, we compared cortico-hippocampal connectivity using intrinsic functional connectivity MRI (fcMRI) in awake mice and humans.
![hippocampus anatomy and visual cortex mouse hippocampus anatomy and visual cortex mouse](https://media.springernature.com/original/springer-static/image/chp%3A10.1007%2F978-3-030-19898-5_10/MediaObjects/459632_1_En_10_Fig31_HTML.png)
A central question in brain evolution is how cortical development affected the nature of cortical inputs to the hippocampus. While the hippocampal memory system has been relatively conserved across mammals, the cerebral cortex has undergone massive expansion.